Development of Economic Transdermal Patches Containing Lornoxicam for Treatment of Acute and Chronic Inflammatory Models in Albino Rats (a Preclinical Study)

Objective: To formulate economic transdermal patch of lornoxicam (LX) and to study its anti-inflammatory activity on acute and chronic inflammatory in rat models Method: Three LX transdermal patches (F1, F2 and F3) consist of Eudragit RL-100 and RS-100 in three different ratios (1:2, 1:1 and 2:1) were prepared respectively by the solvent evaporation technique. All formulations contain diethylphthalate as plasticizer. The physicochemical compatibility of the drug and the polymers was studied by differential scanning colorimetry. The prepared LX transdermal patches were evaluated for their drug content, patch thickness, folding endurance, surface pH and in vitro drug permeation. The anti-inflammatory activity of LX transdermal patch was determined using two animal experimental designs one for acute inflammation ( rat paw edema) and the other for chronic inflammation (granuloma pouch) on eighty adult albino rats. The results obtained were statistically analyzed. Results: The data showed physicochemical compatibility between the drug and the polymers used. The LX patches (F1, F2 and F3) prepared were uniform thickness, drug content and the pH of LX patch was found to be 6.5. Increasing the ratio of the Eudragit ® RL-100 polymer to eudragit RS 100 (F3) showed a corresponding increase in the folding endurance of patches. Diethyl phthalate led to increase elasticity for the patches. F3 showed higher drug permeation than F2 and F1. Edema (anti-inflammatory effect) was significantly decreased in group V followed by group IV then by group III in case of the two animal experimental designs. Group V received LX transdermal patch (F3). Conclusion: The present study showed that the prepared economic lornoxicam transdermal patch has good properties with a high efficiency as an anti-inflammatory drug on acute and chronic inflammatory models. INTRODUCTION: Inflammation is a reaction of tissue to injury, expressed by five cardinal points: pain, swelling, redness, heat, and loss of function. Inflammation and pain relieving drugs are the most commonly used drugs worldwide either through prescription or as over the counter medication.